5 questions: Chang on antidepressants in
kids An occasional feature in which a
School of Medicine expert answers five questions on a science or
policy topic of interest to the Stanford
community
1. Do teens really need antidepressants -- isn't it
normal for them to experience depression and
moodiness?
Chang: Well, some do and some don't. It can be
tricky to tell the difference between normal teen moodiness and an
actual mood disorder that needs treatment, which is why it's
important to involve a qualified mental health professional in the
diagnosis. Between 8 and 9 percent of teens have depression or
anxiety that needs some type of intervention, be it therapy,
medication or a combination of the two.
2. Are mental health problems increasing in children or are
we just diagnosing them more?
Chang: I believe we're diagnosing them more. We're
realizing more and more that we're not dealing solely with poor
parenting or children who can't cope. Genetics play a role, and
there may be environmental components as well that we haven't yet
identified. In the past many of these children went undiagnosed and
untreated.
3. If my child is on antidepressants, should I be
worried?
Chang: Not worried, but aware. If prescribed to
the wrong child, selective serotonin reuptake inhibitors, or SSRIs,
can cause unusual or erratic behavior, angry outbursts, decreased
need for sleep and suicidal gestures. Some of these children may be
in the early stages of bipolar disorder, which requires a very
different type of medication. But as a parent, I wouldn’t
decide not to treat my child solely due to a fear of the
medication.
4. Why do these medications increase suicide risk mostly in
kids? It seems counterintuitive when the medication is actually
meant to make them feel better.
Chang: Children may respond to psychiatric
medications differently than adults because their brains -- like
their bodies -- are still developing. For example, tricyclic
antidepressants, which can be effective in adults with depression,
don’t really work in children. Also, it can be difficult to
differentiate between depression and early bipolar disorder in
adolescents. Because SSRIs can cause simultaneous manic and
depressive states in people with bipolar disorder, which can lead
to an increased suicide risk, it's vital to ask whether there's a
family history of bipolar disorder or if the child has ever
responded negatively to other psychiatric medications.
5. Do you think the new warning labels will change
prescription patterns?
Chang: I'm concerned that physicians will start
shying away from prescribing these medications appropriately, which
could have negative consequences for patients. These medications
can be lifesavers, but just like any medication they need to be
prescribed and monitored carefully. The outcome of an untreated
child with true depression is very poor.
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Lucile Packard Children's Hospital child
psychiatrist Kiki Chang, MD, studies the genetic underpinnings and
treatment of bipolar disease. The assistant professor at the School
of Medicine comments on the recent Food and Drug Administration
recommendation to include labels on 10 newer-generation
antidepressants -- including Prozac, Paxil and Zoloft -- warning of
an increased risk of suicide, particularly in children taking the
drugs.
5 questions: Paul Berg on ideology in science (3/3/04)
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